五黄养阴颗粒治疗2型糖尿病合并脂代谢异常临床研究

目的观察五黄养阴颗粒治疗2型糖尿病合并脂代谢异常的临床疗效。方法选择458例门诊患者随机分为两组,A组给予五黄养阴颗粒,B组给予糖脉康。比较两组患者治疗前后血糖疗效。结果两组患者在0周与8周时空腹血糖值比较,A组患者血糖、糖化血红蛋白、血脂及中医证候疗效指标均优于B组。结论五黄养阴颗粒治疗2型糖尿病合并脂代谢异常的临床疗效可靠,且未发现不良反应。     

Land use change, biomass production and HANPP: The case of Hungary 1961-2005

This paper presents an empirical analysis of the human appropriation of aboveground net primary production (aHANPP) in Hungary in the years 1961-2005. In this period aboveground HANPP dropped from 67% to 49% of the potential vegetation's NPP. The trajectory was not smooth, but aboveground HANPP fluctuated with changes in factors affecting agricultural production conditions. Both aboveground net primary production (aNPP) of the prevailing vegetation and harvested aNPP increased during the socialist regime, dropped when the system collapsed and has shown considerable fluctuations since. We discuss the development of aboveground HANPP and the Hungarian land use system in the context of socioeconomic changes during three distinct phases: (1) industrialisation of agriculture (1961-1989), (2) regime collapse (1989-1993) and (3) restructuring of a new economy (1993-2005). Within these periods, different driving factors influenced aboveground HANPP and its constituents. In the phase of industrialisation, mechanisation and agrochemical inputs reduced aHANPP while harvested amounts of biomass increased progressively. In the second phase, political and economic circumstances devastated production conditions resulting in a decline of productivity of actual vegetation and a temporary rise in aboveground HANPP. During the last twelve years, industrialisation patterns of agricultural production recovered. The restructuring of inefficient agricultural production systems raised harvest at moderate levels of agricultural inputs, while climatic conditions intimidated high yield and harvest security. The paper discusses the effect of different economic and political regimes and of major socioeconomic restructuring on the development of the land use system, biomass production and aboveground HANPP.     

Contaminant,Commodity and Fuel: A Multi-sited Study of Waste's roles in Urban Transformations from Italy to Austria

This article traces the flow of municipal solid waste from southern Italy through a waste-to-energy facility and district heating system in Austria, examining the roles that waste's transformation from contaminant to commodity to fuel plays in interconnected, distributed, and contested urbanization processes. It contends that, while metabolic circulation hides socioecological costs in one place to facilitate valorization in another, specific spatial configurations emerge through territorialization—of waste economies, in this case—providing the spatial base to realize metabolic flows and to anchor political narratives. A decisive effect is that certain patterns of urbanization become locked-in, impeding alternative metabolic transitions and spatial configurations. Attending to the coproduction of three sites—Naples, Italy; Zwentendorf, Austria; and St Pölten, Austria—through the circulation and transformation of waste and energy the article provides an empirical multi-sited case study of a political ecology of urbanization.     

Infrastructure's Expenditures: Changi Airport,Food Cargo and Capital's Technosphere

Urban research has long maintained that an unwavering link exists between urbanization and infrastructures, with the latter serving as structuring devices that give material and discursive shape to a city's socio‐ecological composition. But, while infrastructures’ mediative power and consequent ecological effects are well established, present scholarship tends to associate them with only a specific set of metabolisms—namely, those tied to urban (re)production—at the expense of wider capitalist projects that may exceed discrete urbanisms. Complexifying this view, this article posits that infrastructures can constitute larger systems and frameworks that help capital achieve networked forms of accumulation. Specifically, it follows recent theorizations on the technosphere—artificialized environments of interacting systems—to demonstrate how infrastructures help drive particular dispositions and modes of production and consumption beyond cities. Through documentary analyses and interviews with industry players, the article uses the emergent food cargo business at Singapore's Changi Airport as an empirical case to exemplify the enfolding of one such technosphere through infrastructures. It shows how paying heed to these technospheric formations exposes hidden expenditures—in this instance, of land, energy and labour—that not only underpin a global regime of (food) circulation, but also result in additional socio‐ecological costs often omitted in urban research.     

丁酸梭菌甘油发酵代谢机理研究进展

本文对丁酸梭菌在甘油转化成1,3-丙二醇的过程中代谢规律及代谢控制的相关酶作以综述,同时分析了产物的抑制作用及影响因素,对未来的研究发展方向进行展望.     

Explaining Japan's Unproductive Two Decades

Using industry‐ and micro‐level data, this paper examines why Japan's productivity growth has been slow for such a long time and how it can be accelerated in the future. Japan's capital–gross domestic product ratio continued to increase after 1991, and this increase in the capital–gross domestic product ratio must have contributed to the decline in the rate of return on capital in Japan by decreasing the marginal productivity of capital. On the other hand, Japan's accumulation of information and communication technology capital and intangible investment was very slow. Compared with large firms, which enjoyed an acceleration in the total factor productivity growth in recent years, Japanese small‐ and medium‐sized enterprises were left behind in information and communication technology capital and intangible investment, and their productivity growth has been very low. Furthermore, as large firms expanded their supply chains globally and relocated their factories abroad, research and development spillovers from large firms to small‐ and medium‐sized enterprises seem to have declined.     

Examining and interpreting responsiveness of the Diabetes Medication Satisfaction measure

Abstract

Objective: Treatment satisfaction (TS) is an important patient reported outcome (PRO) in diabetes as it is correlated with outcomes necessary for optimal treatment (e.g., compliance, self-management behaviour). The objective of this study was to examine the responsiveness of the DiabMedSat, a disease-specific PRO measure, assessing Overall, Burden, Efficacy and Symptom TS.

Methods: The DiabMedSat was included in an open label, observational study of the safety and efficacy of biphasic insulin aspart 30 (NovoMix 30) in routine practice with type 2 diabetes. Responsiveness analyses, examining both internal and external responsiveness, were conducted and minimally important differences (MID) assessed.

Results: In 18,817 patients, all TS scores significantly improved after 26 weeks of treatment (p<0.001). The effect sizes for these changes were above 0.5 indicating that the ability to detect change was moderate-to-large in size. Significant differences were found for all TS scores comparing patients who met their HbA_1c goal, who improved but did not meet goal and who did not improve (p<0.01), and for patients who experienced a minor hypoglycaemic event and those who did not (p<0.001). DiabMedSat scores were able to detect changes in patients’ own global rating of satisfaction (MID ranging from 5.3 to 11.7) and in physician-rated satisfaction with patients’ HbA_1c improvement (MID ranging from 5.3 to 10.2).

Conclusions: In the context of an observational study, the DiabMedSat has been shown to be highly responsive to change and can be considered as an acceptable PRO measure for TS in diabetes.     

糖尿病教育在糖尿病综合治疗中的作用研究

为探讨糖尿病教育对糖尿病患者血糖水平的影响,将已确诊糖尿病的164例门诊患者随机分为观察组和对照组。观察组在对照组药物治疗的基础上增加半年糖尿病教育。观察组82例患者糖尿病相关知识掌握程度良好,血糖控制较对照组有明显改善。糖尿病教育可明显改善糖尿病患者的血糖控制水平。     

心理治疗对2型糖尿病肾病治疗效果的影响

为探讨心理治疗对2型糖尿病肾病(T2DN)治疗效果的影响,选择2型糖尿病肾病患者94例,随机分为对照组和观察组,每组47例。对照组行常规治疗,观察组在对照组的基础上进行相应的心理治疗,6个月后分别检测并分析2组患者的空腹血糖(FPG)、糖化血红蛋白(HbA1C)及24 h尿白蛋白(24hUAlb)水平。结果为:观察组患者FPG、HbA1C及24 hUAlb水平均较对照组明显改善,2组之间比较均存在统计学差异(P<0.05)。心理治疗可提高2型糖尿病肾病的治疗效果。     

Biomass consumed in anthropogenic vegetation fires: Global patterns and processes

Human-induced vegetation fires destroy a large amount of biomass each year and thus constitute an important fraction of the human interference with the energy flows of terrestrial ecosystems. This paper presents a quantification of the biomass burned in large-scale as well as small-scale human-induced vegetation fires at the country level for the year 2000. The amount of biomass burned in large scale fires is estimated combining information on the amount of biomass destroyed by large vegetation fires each year, derived by remote sensing, with estimates about the fraction induced by human activities. For biomass flows resulting from shifting cultivation, no comprehensive information is available at the global scale. Therefore, this flow was modelled on the basis of data on the area subjected to shifting cultivation and assumptions about the typical length of the cropping and fallow periods and the amount of biomass destroyed in each rotation cycle. The results show that the amount of biomass consumed in anthropogenic vegetation fires ranges between 3.5 and 3.9 billion tons dry matter per year (Pg dm/yr), a considerable amount when compared to the global socioeconomic biomass harvest of 12 Pg dm/yr. One third of the biomass consumed in anthropogenic fires each year, 1.0-1.4 Pg dm, results from shifting cultivation. Anthropogenic fires are most important in the regions of Sub-Saharan Africa (2202 Tg dm/yr), Latin America (795 Tg dm/yr), South-Eastern Asia (336 Tg dm/yr) and Central Asia (157 Tg dm/yr), whereas in regions dominated by industrialized countries, anthropogenic vegetation fires play a minor role. Due to the lack of consistent and spatially explicit data for the year 2000, these numbers do not include agricultural residues burned in the field. The inclusion of residue burning in the year 1985 would increase the total biomass consumed by 0.45 Pg dm to a total of between 4.0 and 4.4 Pg dm/yr. The paper shows that the current geographic pattern of biomass burning can be explained by a combination of natural factors, such as the type of the potential vegetation, and socioeconomic factors, such as population density and the degree of industrialization of a region, which ultimately determine the application of vegetation fires in land use management. It is expected that the magnitude of anthropogenic vegetation fires will decrease in absolute and relative terms, mainly due to population growth and the diffusion of modern land use technologies, which more and more replace the function of vegetation fires as a land management tool.